Cell-cell interactions are fundamental
to multicellular organisms. Epithelial and endothelial cells exist only in groups surrounded by neighbors. Cell-cell interactions between
epithelial and endothelial cells provide platforms for cell-cell adhesion and signalling.
The regulation of epithelial and endothelial cell-cell interactions is
very complex and requires efforts from multiple disciplines
including basic cellular and molecular
methods as well as biophysical and bioinformatics approaches.