Tang Lab Research

Regulation of epithelial and endothelial functions
Actin regulation at cell-cell junction
Adhesion Regulation at Cell-Cell Contacts
Mechanobiology of cell-cell junction
Biomolecular EM of junctional complexes
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Forces at Junction

Our laboratory focuses on 2 main topics surrounding cell-cell adhesive contacts.  First, we aim to understand the role of cell-cell adhesive contacts in essential epithelial functions including permeability barrier formation and wound healing.   Second, we aim to dissect the molecular mechanism of junction regulation during health and disease.  The overall goal of the lab is to understand how mutations in junctional molecules such as alpha-actinin-4, CD2AP, and synaptopodin leads to loss of barrier functions of the epithelial cells.


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