Our laboratory focuses
on 2 main topics surrounding cell-cell adhesive contacts.
First, we aim to understand the role of cell-cell adhesive
contacts in essential epithelial functions including permeability barrier formation and
wound healing. Second, we aim to dissect
the molecular mechanism of junction regulation during health and disease.
The overall goal of the lab is to understand how mutations in junctional
molecules such as alpha-actinin-4, CD2AP, and synaptopodin
leads to loss of barrier functions of the epithelial cells.