Tight Junction Function
TJ Proteins
TJ Function
TJ Environment
TJ Regulation
TJ Channel
TER vs Flux
TJ Maintenance
Tight Junction is a dynamic structure with different functions.  Its disruption, regardless of the cause, almost certainly leads to a disease state.

Although most studies have focused on permeability (barrier function), polarity (fence function), and signaling (growth regulation), there are many processes associated with the tight junction that have no molecular and mechanistic explanations.
Outstanding Questions:

(i) intercellular mechanisms that allow cell-cell communication, 

(ii) signaling pathways that lead to regulation of contact inhibition of cell migration, and proliferation,

(iii) molecular events that lead to targeting and recruitment of the tight junction scaffold, 

(iv) mechanisms that lead to assembly of tight junction membrane micro-domain, paracellular channels, and intramembraneous strands, 

(v) extracellular adhesive interactions and their regulation, 

(vi) intracellular cytoskeletal interactions and their regulation, 

(vii) contribution to morphogenesis and tensile strength of the epithelial sheet, 

(viii) maintenance of a steady-state through regulation of protein synthesis and membrane recycling, and 

(ix) generation of polarity during differentiation and epithelialization.

The current knowledge of known tight junction proteins is far from explaining even one of these complex processes.

click here to play Fence video


click here to play Permeability video


click here to play Signaling video


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